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Research Proposal
Speech understanding
Inferior colliculus lesions
Brainstem aphasia
fMRI of the inferior colliculi
Testing strategies
Anticipated results

Working hypotheses
Language areas on fMRI
Effects of asphyxia at birth
Maturation of the brain
Time-table of myelination
Learning to speak "by ear"
Metabolism in the brain
Protective mechanisms
Catastrophic factors
Brainstem damage
Cardiac Arrest Encephalopathy:
Damage restricted to the brainstem is only seen after total interference
with aerobic metabolism occurs; Janzer and Friede (1980) referred to
brainstem pathology as "cardiac arrest encephalopathy;" this was the
case in monkeys subjected to several minutes of total asphyxia at birth.
Myers (1972) found that prolonged partial hypoxia late in
gestation caused damage to wide areas of the cerebral cortex,
which was thought  far more important that the brainstem pattern.
This was cerebral palsy!
Miller and Myers  (1970, 1972) found also that adult monkeys
sustained brainstem damage with complete circulatory arrest, and
widespread cortical damage with partial circulatory insufficiency.
Janzer RC, Friede RL. Hypotensive brain stem necrosis or cardiac arrest encephalopathy?
Acta Neuropathol (Berl). 1980;50(1):53-6.
Myers RE (1972) Two patterns of perinatal brain damage and their conditions of occurrence.
American Journal of Obstetrics and Gynecology 112:246-276
Miller JR, Myers RE (1970) Neurological effects of systemic circulatory arrest in the monkey.
Neurology 20:715-724.
Miller JR, Myers RE (1972) Neuropathology of systemic circulatory arrest in adult monkeys.
Neurology 22:888-904.
October 2006
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